Oxytetracycline biosynthesis improvement in Streptomyces rimosus following duplication of minimal PKS genes.

@article{Yu2012OxytetracyclineBI,
  title={Oxytetracycline biosynthesis improvement in Streptomyces rimosus following duplication of minimal PKS genes.},
  author={Lan Yu and Nan Cao and Long Wang and Ciying Xiao and Meijin Guo and Ju Chu and Yingping Zhuang and Siliang Zhang},
  journal={Enzyme and microbial technology},
  year={2012},
  volume={50 6-7},
  pages={318-24}
}
Oxytetracycline (OTC) is a widely used antibiotic, which is commercially produced by Streptomyces rimosus. The type II minimal polyketide synthases (minimal PKS) genes of the oxytetracycline biosynthesis cluster in S. rimosus, consisting of oxyA, oxyB and oxyC, are involved in catalyzing 19-C chain building by the condensation of eight malonyl-CoA groups to form the starting polyketide. This study aimed to investigate the effects of overexpression of the minimal PKS gene in a model S. rimosus… CONTINUE READING

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