Oxysterols induce interleukin-1beta production in human macrophages.

@article{Rosklint2002OxysterolsII,
  title={Oxysterols induce interleukin-1beta production in human macrophages.},
  author={T. Rosklint and Bertil G. Ohlsson and Olov Wiklund and Kristina Nor{\'e}n and Lillemor Mattsson Hult{\'e}n},
  journal={European journal of clinical investigation},
  year={2002},
  volume={32 1},
  pages={
          35-42
        }
}
BACKGROUND Oxysterols are biologically active molecules generated during the oxidation of low-density lipoprotein or formed enzymatically in vivo. In the atherosclerotic plaque newly recruited macrophages may be exposed to oxysterols present in the plaque. How these oxysterols affect the expression and secretion of inflammatory cytokines such as interleukin-1beta (IL-1beta) in macrophages is not known. Therefore the aim of the present study was to investigate how oxysterols regulate the… CONTINUE READING
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