Oxysterols induce differentiation in human keratinocytes and increase Ap-1-dependent involucrin transcription.

@article{Hanley2000OxysterolsID,
  title={Oxysterols induce differentiation in human keratinocytes and increase Ap-1-dependent involucrin transcription.},
  author={Karen P. Hanley and Dean C Ng and S. S. He and Peggy Pei Zhi Lau and K -T. Min and Peter M Elias and Daniel D Bikle and David J Mangelsdorf and Mary Lou Williams and Kenneth R. Feingold},
  journal={The Journal of investigative dermatology},
  year={2000},
  volume={114 3},
  pages={545-53}
}
Ligands and activators of the nuclear hormone receptor superfamily are important in the regulation of epidermal development and differentiation. Previously, we showed that naturally occurring fatty acids, as well as synthetic ligands for the peroxisome proliferator-activated receptor, induce keratinocyte differentiation in vitro. Here we asked whether oxysterols, another class of lipids formed de novo in the epidermis and that activate liver X-activated receptor, regulate keratinocyte… CONTINUE READING
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