Oxysterols are substrates for cholesterol sulfotransferase.

  title={Oxysterols are substrates for cholesterol sulfotransferase.},
  author={Hirotoshi Fuda and Normal B Javitt and Kuniko Mitamura and Shigeo Ikegawa and Charles A Strott},
  journal={Journal of lipid research},
  volume={48 6},
Oxysterols constitute a class of cholesterol derivatives that exhibit broad biological effects ranging from cytotoxicity to regulation of nuclear receptors. The role of oxysterols such as 7-ketocholesterol (7-KC) in the development of retinal macular degeneration and atheromatous lesions is of particular interest, but little is known of their metabolic fate. We establish that the steroid/sterol sulfotransferase SULT2B1b, known to efficiently sulfonate cholesterol, also effectively sulfonates a… CONTINUE READING
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Oxysterol-induced up-regulation ofMCP-1 expression inmacrophage cells

  • G. Leonarduzzi, P. Gamba, +7 authors A. Sevanian
  • Free Radic. Biol. Med
  • 2005
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