Oxysterols are allosteric activators of the oncoprotein Smoothened

  title={Oxysterols are allosteric activators of the oncoprotein Smoothened},
  author={Sigrid Nachtergaele and Laurel K. Mydock and K. Amrutha Krishnan and Jayan Rammohan and Paul H Schlesinger and Douglas F Covey and Rajat Rohatgi},
  booktitle={Nature chemical biology},
Oxysterols are a class of endogenous signaling molecules that can activate the Hedgehog pathway, which has critical roles in development, regeneration and cancer. However, it has been unclear how oxysterols influence Hedgehog signaling, including whether their effects are mediated through a protein target or indirectly through effects on membrane properties. To answer this question, we synthesized the enantiomer and an epimer of the most potent oxysterol, 20(S)-hydroxycholesterol. Using these… CONTINUE READING

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