Oxyntomodulin ameliorates glucose intolerance in mice fed a high-fat diet.

@article{Parlevliet2008OxyntomodulinAG,
  title={Oxyntomodulin ameliorates glucose intolerance in mice fed a high-fat diet.},
  author={Edwin T. Parlevliet and Annemieke C Heijboer and Janny P. Schr{\"o}der-van der Elst and Louis M. Havekes and Johannes Anthonius Romijn and Hanno Pijl and Eleonora P. M. Corssmit},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2008},
  volume={294 1},
  pages={E142-7}
}
We evaluated the acute effects of OXM on glucose metabolism in diet-induced insulin-resistant male C57Bl/6 mice. To determine the effects on glucose tolerance, mice were intraperitoneally injected with OXM (0.75, 2.5, or 7.5 nmol) or vehicle prior to an ip glucose tolerance test. OXM (0.75 nmol/h) or vehicle was infused during a hyperinsulinemic euglycemic clamp to quantify insulin action on glucose production and disposal. OXM dose-dependently improved glucose tolerance as estimated by AUC for… CONTINUE READING

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by improving insulin sensitivity and reducing hepatic gluconeogenesis

  • EY Lui, SL Asa, DJ Drucker, YC Lee, PL Brubaker
  • 2007

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