Oxymorphazone: A long-acting opiate analgesic

@article{Ling2004OxymorphazoneAL,
  title={Oxymorphazone: A long-acting opiate analgesic},
  author={Geoffrey S. F. Ling and Steven L. Galetta and Gavril W. Pasternak},
  journal={Cellular and Molecular Neurobiology},
  year={2004},
  volume={4},
  pages={1-13}
}
Summary1.Treating rat brain homogenatesin vitro with oxymorphazone, the hydrazone derivative of oxymorphone, selectively inhibited in a long-acting manner the highaffinity (mu1) binding of a number of3H-opioids. This inhibition was not affected by extensive wash procedures which did effectively reverse classical opiates such as morphine and naloxone.2.A similar, persistent inhibition of binding was observed followingin vivo administration of the drug. Both systemically and… Expand
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Effects of opioid analgesics on the action of general anaesthetics
The air-dried, milky exudation obtained by incising the unripe capsules of papaver somniferum, or its variety album, have been used for many hundreds of years to relieve pain. The chief narcoticExpand

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