Oxymetazoline inhibits proinflammatory reactions: effect on arachidonic acid-derived metabolites.

  title={Oxymetazoline inhibits proinflammatory reactions: effect on arachidonic acid-derived metabolites.},
  author={Ingrid Beck-Speier and Niru Dayal and Erwin W Karg and Konrad Ludwig Maier and Gabriele Schumann and Manuela Semmler and Stephan M Koelsch},
  journal={The Journal of pharmacology and experimental therapeutics},
  volume={316 2},
The nasal decongestant oxymetazoline effectively reduces rhinitis symptoms. We hypothesized that oxymetazoline affects arachidonic acid-derived metabolites concerning inflammatory and oxidative stress-dependent reactions. The ability of oxymetazoline to model pro- and anti-inflammatory and oxidative stress responses was evaluated in cell-free systems, including 5-lipoxygenase (5-LO) as proinflammatory, 15-lipoxygenase (15-LO) as anti-inflammatory enzymes, and oxidation of methionine by… CONTINUE READING


Publications citing this paper.
Showing 1-9 of 9 extracted citations


Publications referenced by this paper.
Showing 1-10 of 40 references

Similar Papers

Loading similar papers…