Oxymetazoline inhibits proinflammatory reactions: effect on arachidonic acid-derived metabolites.

@article{BeckSpeier2006OxymetazolineIP,
  title={Oxymetazoline inhibits proinflammatory reactions: effect on arachidonic acid-derived metabolites.},
  author={Ingrid Beck-Speier and Niru Dayal and Erwin W Karg and Konrad Ludwig Maier and Gabriele Schumann and Manuela Semmler and Stephan M Koelsch},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2006},
  volume={316 2},
  pages={843-51}
}
The nasal decongestant oxymetazoline effectively reduces rhinitis symptoms. We hypothesized that oxymetazoline affects arachidonic acid-derived metabolites concerning inflammatory and oxidative stress-dependent reactions. The ability of oxymetazoline to model pro- and anti-inflammatory and oxidative stress responses was evaluated in cell-free systems, including 5-lipoxygenase (5-LO) as proinflammatory, 15-lipoxygenase (15-LO) as anti-inflammatory enzymes, and oxidation of methionine by… CONTINUE READING

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