Oxymatrine protects rat brains against permanent focal ischemia and downregulates NF-kappaB expression.

BACKGROUND Oxymatrine is proven to protect ischemic and reperfusion injury in liver, intestine and heart, this effect is via anti-inflammation and anti-apoptosis. Whether this protective effect applies to ischemic injury in brain, we therefore investigate the potential neuroprotective role of oxymatrine and the underlying mechanisms. METHODS Male, Sprague… CONTINUE READING