Oxyhemoglobin-induced suppression of voltage-dependent K+ channels in cerebral arteries by enhanced tyrosine kinase activity.

@article{Ishiguro2006OxyhemoglobininducedSO,
  title={Oxyhemoglobin-induced suppression of voltage-dependent K+ channels in cerebral arteries by enhanced tyrosine kinase activity.},
  author={Masanori Ishiguro and Anthony D. Morielli and Katarina Zvarova and Bruce I. Tranmer and Paul L. Penar and George C. Wellman},
  journal={Circulation research},
  year={2006},
  volume={99 11},
  pages={1252-60}
}
Cerebral vasospasm following aneurysmal subarachnoid hemorrhage (SAH) has devastating consequences. Oxyhemoglobin (oxyhb) has been implicated in SAH-induced cerebral vasospasm as it causes cerebral artery constriction and increases tyrosine kinase activity. Voltage-dependent, Ca(2+)-selective and K(+)-selective ion channels play an important role in the regulation of cerebral artery diameter and represent potential targets of oxyhb. Here we provide novel evidence that oxyhb selectively… CONTINUE READING