Oxyhemoglobin as the principal cause of cerebral vasospasm: a holistic view of its actions.

@article{Asano1999OxyhemoglobinAT,
  title={Oxyhemoglobin as the principal cause of cerebral vasospasm: a holistic view of its actions.},
  author={Yoshitaka Asano},
  journal={Critical reviews in neurosurgery : CR},
  year={1999},
  volume={9 5},
  pages={
          303-318
        }
}
While oxyhemoglobin (oxyHb) is deemed to be the principal cause of cerebral vasospasm following subarachnoid hemorrhage, the mechanism(s) whereby it leads to vasospasm is by no means clear. Of importance is the fact that prolonged contraction of arterial smooth muscle is not the sole feature of cerebral vasospasm, particularly in humans. Vasospasm is also associated with the occurrence of organic changes in the arterial wall as well as the derangement of cerebral microcirculation. These… CONTINUE READING
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