Oxygenation‐sensitive contrast in magnetic resonance image of rodent brain at high magnetic fields

  title={Oxygenation‐sensitive contrast in magnetic resonance image of rodent brain at high magnetic fields},
  author={Seiji Ogawa and Tso‐Ming Lee and Asha S. Nayak and Paul Glynn},
  journal={Magnetic Resonance in Medicine},
At high magnetic fields (7 and 8.4 T), water proton magnetic resonance images of brains of live mice and rats under pentobarbital anesthetization have been measured by a gradient echo pulse sequence with a spatial resolution of 65 × 65‐μm pixel size and 700‐μm slice thickness. The contrast in these images depicts anatomical details of the brain by numerous dark lines of various sizes. These lines are absent in the image taken by the usual spin echo sequence. They represent the blood vessels in… 
Magnetic resonance imaging of blood vessels at high fields: In vivo and in vitro measurements and image simulation
This description of the contrast enhancement has been confirmed by a series of in vitro blood sample experiments and image simulations and a predicted contrast change has been demonstrated in brain images of a mouse placed at two different orientations in the magnet.
Toward absolute quantitation of bold functional MRI.
It is only the change in concentration of deoxyhemoglobin, due to a short-lived and/or transient physiological perturbation, that is important for being able to quantitate the BOLD signal change for functional MRI (see Appendix).
Quantitative Measurements of Cerebral Blood Oxygen Saturation Using Magnetic Resonance Imaging
  • H. An, Weili Lin
  • Medicine, Biology
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
  • 2000
Although further studies are needed to overcome some of the confounding factors affecting the estimates of cerebral blood oxygen saturation, these preliminary results are encouraging and should open a new avenue for the noninvasive investigation of cerebral oxygen metabolism under different pathophysiologic conditions using a magnetic resonance imaging approach.
High-Resolution Functional Magnetic Resonance Imaging of the Rat Brain: Mapping Changes in Cerebral Blood Volume Using Iron Oxide Contrast Media
High-resolution magnetic resonance imaging was used to produce high-resolution activation maps reflecting local changes in cerebral blood volume after a simple sensory stimulus and an injection of an intravascular iron oxide contrast agent enhanced the effect.
A Primer on MRI and Functional MRI
Functional brain mapping with magnetic resonance imaging (MRI) is a rapidly growing field that has emerged in only the past several years. Functional MRI (fMRI) is the use of MRI equipment to detect
High-resolution venography of the brain using magnetic resonance imaging
Preliminary results in patients with cerebral arteriovenous malformations indicate its potential in clinical applications and the proposed method is easy to implement and does not require administration of a contrast agent or application of specially designed rf pulses to highlight the veins.
The sensitivity of magnetic resonance image signals of a rat brain to changes in the cerebral venous blood oxygenation
From observations and image simulations, the extent of the signal response to some neuro‐stimulation which induces an increase in regional cerebral blood flow has been estimated for 4 T field strength.
Functional magnetic resonance imaging of the human brain: data acquisition and analysis
It is shown that patterns of activation obtained in human brain for a given stimulus are independent of the order and spatial orientation with which MRI images are acquired, and hence that inflow effects are not important for EPI data with a TR much longer than T1.
High field human imaging
  • D. Norris
  • Physics
    Journal of magnetic resonance imaging : JMRI
  • 2003
This review article examines the state of knowledge regarding human imaging using MRI at high main magnetic field strengths in the range of 3–8 T with special reference to sensitivity, power deposition, and homogeneity and focuses on vascular imaging.


Magnetic resonance imaging of stationary blood: a review.
The magnetic resonance imaging appearance of blood, as with other body tissues, is affected strongly by magnetic relaxation rates of the water protons, which have important consequences for magnetic resonance Imaging of hematomas.
Direct FLASH MR imaging of magnetic field inhomogeneities by gradient compensation
The effects of local gradients in rapid FLASH MR images and a way of directly imaging affected areas is presented to compensate for signal losses due to mutual cancellation of dephased magnetizations by deliberate “misadjustments” of the refocusing part of the slice selection gradient.
Rapid scan magnetic resonance angiography
The change in phase of transverse spin magnetization induced by macroscopic spin motion in the direction of an applied magnetic field gradient is used to generate projection angiograms. The method
19F NMR imaging of blood oxygenation in the brain
Perfluorcarbon emulsions have been developed as oxygen carrying blood substitutes and 19F NMR imaging of blood vessels are formed and pO2 maps of the cat brain are calculated.
Application of spin-echo nuclear magnetic resonance to whole-cell systems. Membrane transport.
A new method for studying membrane transport using spin-echo techniques and relies on a difference in the magnetic susceptibility of the media inside and outside of cells to provide simultaneous information on the metabolic status of the cell.
The Rat Brain
  • Figure
  • 1986
WATSON, in “The Rat Brain,
  • 1986