Oxygenation‐sensitive contrast in magnetic resonance image of rodent brain at high magnetic fields

@article{Ogawa1990OxygenationsensitiveCI,
  title={Oxygenation‐sensitive contrast in magnetic resonance image of rodent brain at high magnetic fields},
  author={Seiji Ogawa and Tso‐Ming Lee and Asha S. Nayak and Paul Glynn},
  journal={Magnetic Resonance in Medicine},
  year={1990},
  volume={14}
}
At high magnetic fields (7 and 8.4 T), water proton magnetic resonance images of brains of live mice and rats under pentobarbital anesthetization have been measured by a gradient echo pulse sequence with a spatial resolution of 65 × 65‐μm pixel size and 700‐μm slice thickness. The contrast in these images depicts anatomical details of the brain by numerous dark lines of various sizes. These lines are absent in the image taken by the usual spin echo sequence. They represent the blood vessels in… 

Magnetic resonance imaging of blood vessels at high fields: In vivo and in vitro measurements and image simulation

This description of the contrast enhancement has been confirmed by a series of in vitro blood sample experiments and image simulations and a predicted contrast change has been demonstrated in brain images of a mouse placed at two different orientations in the magnet.

Toward absolute quantitation of bold functional MRI.

It is only the change in concentration of deoxyhemoglobin, due to a short-lived and/or transient physiological perturbation, that is important for being able to quantitate the BOLD signal change for functional MRI (see Appendix).

Quantitative Measurements of Cerebral Blood Oxygen Saturation Using Magnetic Resonance Imaging

  • H. AnWeili Lin
  • Medicine, Biology
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
  • 2000
Although further studies are needed to overcome some of the confounding factors affecting the estimates of cerebral blood oxygen saturation, these preliminary results are encouraging and should open a new avenue for the noninvasive investigation of cerebral oxygen metabolism under different pathophysiologic conditions using a magnetic resonance imaging approach.

High-Resolution Functional Magnetic Resonance Imaging of the Rat Brain: Mapping Changes in Cerebral Blood Volume Using Iron Oxide Contrast Media

High-resolution magnetic resonance imaging was used to produce high-resolution activation maps reflecting local changes in cerebral blood volume after a simple sensory stimulus and an injection of an intravascular iron oxide contrast agent enhanced the effect.

A Primer on MRI and Functional MRI

Functional brain mapping with magnetic resonance imaging (MRI) is a rapidly growing field that has emerged in only the past several years. Functional MRI (fMRI) is the use of MRI equipment to detect

High-resolution venography of the brain using magnetic resonance imaging

Preliminary results in patients with cerebral arteriovenous malformations indicate its potential in clinical applications and the proposed method is easy to implement and does not require administration of a contrast agent or application of specially designed rf pulses to highlight the veins.

The sensitivity of magnetic resonance image signals of a rat brain to changes in the cerebral venous blood oxygenation

From observations and image simulations, the extent of the signal response to some neuro‐stimulation which induces an increase in regional cerebral blood flow has been estimated for 4 T field strength.

Functional magnetic resonance imaging of the human brain: data acquisition and analysis

It is shown that patterns of activation obtained in human brain for a given stimulus are independent of the order and spatial orientation with which MRI images are acquired, and hence that inflow effects are not important for EPI data with a TR much longer than T1.

High field human imaging

  • D. Norris
  • Physics
    Journal of magnetic resonance imaging : JMRI
  • 2003
This review article examines the state of knowledge regarding human imaging using MRI at high main magnetic field strengths in the range of 3–8 T with special reference to sensitivity, power deposition, and homogeneity and focuses on vascular imaging.
...

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