Oxygenated Hypothermic Machine Perfusion After Static Cold Storage Improves Hepatobiliary Function of Extended Criteria Donor Livers

@article{Westerkamp2016OxygenatedHM,
  title={Oxygenated Hypothermic Machine Perfusion After Static Cold Storage Improves Hepatobiliary Function of Extended Criteria Donor Livers},
  author={Andrie C. Westerkamp and Negin Karimian and Alix P. M. Matton and Paria Mahboub and Rianne van Rijn and Janneke Wiersema‐Buist and Marieke T. de Boer and Henri G. D. Leuvenink and Annet S. H. Gouw and Ton Lisman and Robert J. Porte},
  journal={Transplantation},
  year={2016},
  volume={100},
  pages={825–835}
}
Background The mechanism through which oxygenated hypothermic machine perfusion (HMP) improves viability of human extended criteria donor (ECD) livers is not well known. Aim of this study was to examine the benefits of oxygenated HMP after static cold storage (SCS). Methods Eighteen ECD livers that were declined for transplantation underwent ex situ viability testing using normothermic (37°C) machine perfusion (NMP) after traditional SCS (0°C-4°C) for 7 to 9 hours. In the intervention group (n… 

Oxygenated hypothermic machine perfusion after static cold storage improves endothelial function of extended criteria donor livers.

  • L. BurlageN. Karimian R. Porte
  • Medicine, Biology
    HPB : the official journal of the International Hepato Pancreato Biliary Association
  • 2017

Combined Hypothermic and Normothermic Machine Perfusion Improves Functional Recovery of Extended Criteria Donor Livers

  • Y. BoteonR. Laing H. Mergental
  • Medicine, Biology
    Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society
  • 2018
It is suggested that a combined protocol of hypothermic oxygenated and normothermic perfusions might attenuate oxidative stress, tissue inflammation, and improve metabolic recovery of the highest‐risk donor livers compared with normotherm perfusion alone.

An Oxygenated and Transportable Machine Perfusion System Fully Rescues Liver Grafts Exposed to Lethal Ischemic Damage in a Pig Model of DCD Liver Transplantation

This study demonstrates for the first time the efficacy of the HMP Airdrive system to protect liver grafts from lethal ischemic damage before transplantation in a clinically relevant DCD model and was associated with an attenuation of inflammatory response, oxidative load, endoplasmic reticulum stress, mitochondrial damage, and apoptosis.

Hypothermic oxygenated machine perfusion reduces bile duct reperfusion injury after transplantation of donation after circulatory death livers

  • R. van RijnO. V. van Leeuwen R. Porte
  • Medicine
    Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society
  • 2018
It is suggested that DHOPE reduces IRI of bile ducts after DCD liver transplantation as well as other methods to reduce ischemia/reperfusion injury (IRI).

Pretransplant sequential hypo‐ and normothermic machine perfusion of suboptimal livers donated after circulatory death using a hemoglobin‐based oxygen carrier perfusion solution

  • Y. de VriesA. Matton R. Porte
  • Medicine, Engineering
    American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
  • 2019
A protocol of sequential DHOPE, controlled oxygenated rewarming (COR), and NMP using a new hemoglobin‐based oxygen carrier (HBOC)‐based perfusion fluid offers a novel method of liver machine perfusion for combined resuscitation and viability testing of suboptimal livers prior to transplantation.

Transplantation of High-risk Donor Livers After Ex Situ Resuscitation and Assessment Using Combined Hypo- and Normothermic Machine Perfusion: A Prospective Clinical Trial.

Sequential DHOPE-COR-NMP enabled resuscitation and safe selection of initially declined high-risk donor livers, thereby increasing the number of transplantable livers by 20%.

Opposite acute potassium and sodium shifts during transplantation of hypothermic machine perfused donor livers

  • L. BurlageL. Hessels R. Porte
  • Medicine, Biology
    American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
  • 2019
Dual hypothermic oxygenated machine perfusion reduces ischemia/reperfusion injury and improves graft function, compared to conventional static cold storage (SCS), and the effect of DHOPE on ex situ and in vivo shifts of potassium and sodium is examined.

Normothermic machine perfusion of donor livers without the need for human blood products

  • A. MattonL. Burlage R. Porte
  • Medicine, Biology
    Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society
  • 2018
NMP of human donor livers can be performed effectively using HBOC‐201 and gelofusine, eliminating the need for human blood products.

Hypothermic Oxygenated Machine Perfusion of Liver Grafts: Preliminary Experience in a Single Center.

Analysis of early experience in using HOPE in a high-volume liver transplantation center suggests that marginal liver grafts (DCD, ECD-DBD) may be safely used for transplantation improving the outcome, thus effectively enhance the use of a persistent scarce pool of donors.
...

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