Oxygenated Hypothermic Machine Perfusion After Static Cold Storage Improves Hepatobiliary Function of Extended Criteria Donor Livers
@article{Westerkamp2016OxygenatedHM, title={Oxygenated Hypothermic Machine Perfusion After Static Cold Storage Improves Hepatobiliary Function of Extended Criteria Donor Livers}, author={Andrie C. Westerkamp and Negin Karimian and Alix P. M. Matton and Paria Mahboub and Rianne van Rijn and Janneke Wiersema‐Buist and Marieke T. de Boer and Henri G. D. Leuvenink and Annet S. H. Gouw and Ton Lisman and Robert J. Porte}, journal={Transplantation}, year={2016}, volume={100}, pages={825–835} }
Background The mechanism through which oxygenated hypothermic machine perfusion (HMP) improves viability of human extended criteria donor (ECD) livers is not well known. Aim of this study was to examine the benefits of oxygenated HMP after static cold storage (SCS). Methods Eighteen ECD livers that were declined for transplantation underwent ex situ viability testing using normothermic (37°C) machine perfusion (NMP) after traditional SCS (0°C-4°C) for 7 to 9 hours. In the intervention group (n…
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