Oxygenated Hypothermic Machine Perfusion After Static Cold Storage Improves Hepatobiliary Function of Extended Criteria Donor Livers

@article{Westerkamp2016OxygenatedHM,
  title={Oxygenated Hypothermic Machine Perfusion After Static Cold Storage Improves Hepatobiliary Function of Extended Criteria Donor Livers},
  author={Andrie C. Westerkamp and Negin Karimian and Alix P. M. Matton and Paria Mahboub and Rianne van Rijn and Janneke Wiersema‐Buist and Marieke T. de Boer and Henri G. D. Leuvenink and Annet S. H. Gouw and Ton Lisman and Robert J. Porte},
  journal={Transplantation},
  year={2016},
  volume={100},
  pages={825–835}
}
Background The mechanism through which oxygenated hypothermic machine perfusion (HMP) improves viability of human extended criteria donor (ECD) livers is not well known. Aim of this study was to examine the benefits of oxygenated HMP after static cold storage (SCS). Methods Eighteen ECD livers that were declined for transplantation underwent ex situ viability testing using normothermic (37°C) machine perfusion (NMP) after traditional SCS (0°C-4°C) for 7 to 9 hours. In the intervention group (n… 

Oxygenated hypothermic machine perfusion after static cold storage improves endothelial function of extended criteria donor livers.

  • L. BurlageN. Karimian R. Porte
  • Medicine, Biology
    HPB : the official journal of the International Hepato Pancreato Biliary Association
  • 2017

Combined Hypothermic and Normothermic Machine Perfusion Improves Functional Recovery of Extended Criteria Donor Livers

  • Y. BoteonR. Laing H. Mergental
  • Medicine, Biology
    Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society
  • 2018
It is suggested that a combined protocol of hypothermic oxygenated and normothermic perfusions might attenuate oxidative stress, tissue inflammation, and improve metabolic recovery of the highest‐risk donor livers compared with normotherm perfusion alone.

Pretransplant sequential hypo‐ and normothermic machine perfusion of suboptimal livers donated after circulatory death using a hemoglobin‐based oxygen carrier perfusion solution

  • Y. de VriesA. Matton R. Porte
  • Medicine, Engineering
    American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
  • 2019
A protocol of sequential DHOPE, controlled oxygenated rewarming (COR), and NMP using a new hemoglobin‐based oxygen carrier (HBOC)‐based perfusion fluid offers a novel method of liver machine perfusion for combined resuscitation and viability testing of suboptimal livers prior to transplantation.

Transplantation of High-risk Donor Livers After Ex Situ Resuscitation and Assessment Using Combined Hypo- and Normothermic Machine Perfusion: A Prospective Clinical Trial.

Sequential DHOPE-COR-NMP enabled resuscitation and safe selection of initially declined high-risk donor livers, thereby increasing the number of transplantable livers by 20%.

Opposite acute potassium and sodium shifts during transplantation of hypothermic machine perfused donor livers

  • L. BurlageL. Hessels R. Porte
  • Medicine, Biology
    American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
  • 2019
Dual hypothermic oxygenated machine perfusion reduces ischemia/reperfusion injury and improves graft function, compared to conventional static cold storage (SCS), and the effect of DHOPE on ex situ and in vivo shifts of potassium and sodium is examined.

Normothermic machine perfusion of donor livers without the need for human blood products

  • A. MattonL. Burlage R. Porte
  • Medicine, Biology
    Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society
  • 2018
NMP of human donor livers can be performed effectively using HBOC‐201 and gelofusine, eliminating the need for human blood products.

Hypothermic machine perfusion before viability testing of previously discarded human livers

The results from the VITTAL study, with back-to-base endischemic normothermic machine perfusion (NMP) for viability testing of high-risk donor livers, were eagerly awaited as in this field different

Strategies to Restore Adenosine Triphosphate (ATP) Level After More than 20 Hours of Cold Ischemia Time in Human Marginal Kidney Grafts

Hyperbaric or normobaric oxygenation with perfusion improves organ metabolic preservation compared to other methods and may prevent the onset of delayed graft function, but clinical trials are needed to confirm this.

Hypothermic Oxygenated Machine Perfusion of the Human Donor Pancreas

Oxygenated HMP is a feasible and safe preservation method for the human pancreas that increases tissue viability and isolates islets of Langerhans with good viability and in vitro function that could be isolated after HMP.
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