Oxygen transport in hollow fibre membrane bioreactors for hepatic 3D cell culture: A parametric study

  title={Oxygen transport in hollow fibre membrane bioreactors for hepatic 3D cell culture: A parametric study},
  author={S. Khakpour and A. Renzo and E. Curcio and F. Maio and L. Giorno and L. Bartolo},
  journal={Journal of Membrane Science},
  • S. Khakpour, A. Renzo, +3 authors L. Bartolo
  • Published 2017
  • Chemistry
  • Journal of Membrane Science
  • Abstract Hepatic cell cultures are exploited for different applications in liver disease studies, drug toxicity testing and bioartificial liver (BAL) devices. Despite the development of various 3D cell culture systems, mass transfer properties and limitations, especially oxygen supply, still remain a controversial topic. In this paper, oxygen transport in a convection-enhanced, crossed-configuration hollow fibre membrane bioreactor hosting hepatocyte spheroids has been investigated through… CONTINUE READING
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