Oxygen transport in blood at high altitude: role of the hemoglobin–oxygen affinity and impact of the phenomena related to hemoglobin allosterism and red cell function

@article{Samaja2003OxygenTI,
  title={Oxygen transport in blood at high altitude: role of the hemoglobin–oxygen affinity and impact of the phenomena related to hemoglobin allosterism and red cell function},
  author={Michele Samaja and Tiziano Crespi and Marco Guazzi and Kim D. Vandegriff},
  journal={European Journal of Applied Physiology},
  year={2003},
  volume={90},
  pages={351-359}
}
Altitude hypoxia is a major challenge to the blood O2 transport system, and adjustments of the blood–O2 affinity might contribute significantly to hypoxia adaptation. In principle, lowering the blood–O2 affinity is advantageous because it lowers the circulatory load required to assure adequate tissue oxygenation up to a threshold corresponding to about 5,000 m altitude, whereas at higher altitudes an increased blood–O2 affinity appears more advantageous. However, the rather contradictory… CONTINUE READING