Oxygen toxicity in mouse lung: pathways to cell death.

  title={Oxygen toxicity in mouse lung: pathways to cell death.},
  author={Constance Barazzone and Stuart Horowitz and Y. R. A. Donati and Iv{\'a}n Rodr{\'i}guez and Pierre François Piguet},
  journal={American journal of respiratory cell and molecular biology},
  volume={19 4},
Mice exposed to 100% O2 die after 3 or 4 d with diffuse alveolar damage and alveolar edema. Extensive cell death is evident by electron microscopy in the alveolar septa, affecting both endothelial and epithelial cells. The damaged cells show features of both apoptosis (condensation and margination of chromatin) and necrosis (disruption of the plasma membrane). The electrophoretic pattern of lung DNA indicates both internucleosomal fragmentation, characteristic of apoptosis, and overall… CONTINUE READING
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