Oxygen sensitivity of mitochondrial reactive oxygen species generation depends on metabolic conditions.

@article{Hoffman2009OxygenSO,
  title={Oxygen sensitivity of mitochondrial reactive oxygen species generation depends on metabolic conditions.},
  author={David L. Hoffman and Paul S Brookes},
  journal={The Journal of biological chemistry},
  year={2009},
  volume={284 24},
  pages={16236-45}
}
The mitochondrial generation of reactive oxygen species (ROS) plays a central role in many cell signaling pathways, but debate still surrounds its regulation by factors, such as substrate availability, [O2] and metabolic state. Previously, we showed that in isolated mitochondria respiring on succinate, ROS generation was a hyperbolic function of [O2]. In the current study, we used a wide variety of substrates and inhibitors to probe the O2 sensitivity of mitochondrial ROS generation under… CONTINUE READING
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