Oxygen-sensitive Kv channel gene transfer confers oxygen responsiveness to preterm rabbit and remodeled human ductus arteriosus: implications for infants with patent ductus arteriosus.

@article{Thbaud2004OxygensensitiveKC,
  title={Oxygen-sensitive Kv channel gene transfer confers oxygen responsiveness to preterm rabbit and remodeled human ductus arteriosus: implications for infants with patent ductus arteriosus.},
  author={Bernard Th{\'e}baud and Evangelos D Michelakis and X Wu and Rohit Moudgil and Michael A. Kuzyk and Jason R. B. Dyck and Gwyneth I. Harry and Kyoko Hashimoto and Alois Haromy and Ivan M. Rebeyka and Stephen L Archer},
  journal={Circulation},
  year={2004},
  volume={110 11},
  pages={1372-9}
}
BACKGROUND Oxygen (O2)-sensitive K+ channels mediate acute O2 sensing in many tissues. At birth, initial functional closure of the ductus arteriosus (DA) results from O2-induced vasoconstriction. This mechanism often fails in premature infants, resulting in persistent DA, a common form of congenital heart disease. We hypothesized that the basis for impaired O2 constriction in preterm DA is reduced expression and function of O2-sensitive, voltage-gated (Kv) channels. METHODS AND RESULTS… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 42 extracted citations

Circulatory changes associated with the closure of the ductus arteriosus in hatching emu (Dromaius novaehollandiae).

Comparative biochemistry and physiology. Part A, Molecular & integrative physiology • 2016
View 4 Excerpts
Highly Influenced

Maturation of O2 sensing and signaling in the chicken ductus arteriosus.

American journal of physiology. Lung cellular and molecular physiology • 2009
View 5 Excerpts
Highly Influenced

Maturation of the contractile response of the Emu ductus arteriosus

Journal of Comparative Physiology B • 2007
View 6 Excerpts
Highly Influenced

References

Publications referenced by this paper.
Showing 1-10 of 39 references

Mitochondria as vascular oxygen sensors: the redox hypothesis of vascular O2 sensing

ZI Pozeg, B Thebaud, BD Tyrell
2002

The mechanism(s) of hypoxic pulmonary vasoconstriction: potassium channels, redox O(2) sensors, and controversies.

News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society • 2002
View 4 Excerpts

Similar Papers

Loading similar papers…