Oxygen-sensing by ion channels and mitochondrial function in carotid body glomus cells.

@article{LpezBarneo2006OxygensensingBI,
  title={Oxygen-sensing by ion channels and mitochondrial function in carotid body glomus cells.},
  author={Jos{\'e} L{\'o}pez-Barneo and Patricia Ortega-S{\'a}enz and Jos{\'e} Ignacio Piruat and M. Olga Garcia-Fernandez},
  journal={Novartis Foundation symposium},
  year={2006},
  volume={272},
  pages={
          54-64; discussion 64-72, 131-40
        }
}
Carotid body glomus cells release transmitters in response to hypoxia due to the increase of excitability resulting from inhibition of O2-regulated K+ channels. The mechanisms involved in the detection of changes of O2 tension are unknown. Inhibition of the mitochondrial electron transport chain (ETC) at proximal and distal complexes induces external Ca(2+)-dependent catecholamine secretion. At saturating concentration of the ETC inhibitors, the cellular response to hypoxia is maintained… CONTINUE READING
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