Oxygen sensing and hypoxia-induced responses.

@article{Coleman2007OxygenSA,
  title={Oxygen sensing and hypoxia-induced responses.},
  author={Mathew L Coleman and Peter J. Ratcliffe},
  journal={Essays in biochemistry},
  year={2007},
  volume={43},
  pages={
          1-15
        }
}
Low cellular oxygenation (hypoxia) represents a significant threat to the viability of affected tissues. Multicellular organisms have evolved a highly conserved signalling pathway that directs many of the changes in gene expression that underpin physiological oxygen homoeostasis. Oxygen-sensing enzymes in this pathway control the activity of the HIF (hypoxia-inducible factor) transcription factor by the direct incorporation of molecular oxygen into the post-translational hydroxylation of… 
View on PubMed
essays.biochemistry.org
69 Citations
Highly Influential Citations
5
Background Citations
28
Methods Citations
1

Figures from this paper

69 Citations

Citation Type

Citation Type

Hypoxic Response and Associated Diseases
TLDR
Manipulation of the HIF system for therapeutic advantage is an area of medicinal interest because its regulation of HIF directly links changes in oxygen concentration and the physiological response to hypoxia.
Hypoxia and mitochondrial oxidative metabolism.
Oxygen Sensing, Cardiac Ischemia, HIF-1α and Some Emerging Concepts
TLDR
There has been a heightened interest in understanding the biology of HIF-1 in the context of cardiovascular system and the following review describes some of the recent advances in this regard.
The role of hypoxia signalling pathways in normal and leukaemic haemopoiesis
TLDR
The data in this thesis provide evidence that Cited2 is essential for leukaemic transformation at least in part via Mcl-1 regulation and demonstrate that haemopoietic stem and progenitor cells lacking Cite2 display reduced transformation potential and failure to generate transplantable AML in vivo.
Studies on HIF hydroxylases
TLDR
This work characterized the FIH-dependent hydroxylation of the ARD-containing protein Notch1, and defined a consensus sequence for hydroxymation that corresponds to the ankyrin-repeat consensus, indicating that post-translational hydroxyation is likely to be a widespread modification in cell biology.
Role of Nitric Oxide in the Regulation of the Pro-tumourigenic Hypoxic Phenotype: From Instigation to Mitigation
TLDR
How NO can mimic or mitigate the effects of hypoxia in tumours in a context and concentration-dependent manner is described and emerging research suggesting that NO signalling may be harnessed to prevent tumour progression is revealed.
Hypoxia and cancer
TLDR
Although now recognized as a major contributor to cancer progression and to treatment failure, the precise role of hypoxia signalling in cancer and in prognosis still needs to be further defined.
Nitrite Reductase Activity of Cytochrome c*
TLDR
It is demonstrated that in the presence of nitrite, pentacoordinate cytochrome c generates bioavailable NO that is able to inhibit mitochondrial respiration, suggesting an additional role for cy tochrome c as a nitrite reductase that may play an important role in regulating mitochondrial function and contributing to hypoxic, redox, and apoptotic signaling within the cell.
Role of oxygen in cancer: looking beyond hypoxia.
TLDR
A broader view in which the role of oxygen in cancer is not limited to a reduction in its normal levels is discussed, according to this novel view, a deviation of the oxygen metabolism from the pathway that generates energy to the pathways that produces reactive oxygen species is crucial for cancer development.
INTERACTION OF OXYGEN-SENSING MECHANISMS IN CELLS
  • A. Vetosh
  • Biology
    Ulyanovsk Medico-biological Journal
  • 2019
TLDR
The authors analyzed PubMed database using the keywords “intracellular oxygen sensing” to verify the assumption that oxygen-sensing cells are triggered by certain intracellular molecular mechanisms, and discussed the interactional characteristics of the three mechanisms.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 43 REFERENCES
Cellular adaptation to hypoxia: O2‐sensing protein hydroxylases, hypoxia‐inducible transcription factors, and O2‐regulated gene expression
  • R. Wenger
  • Biology
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  • 2002
TLDR
This review aims to summarize the current knowledge of oxygen‐regulated gene expression, which includes the finding that HIF‐1 regulates the expression of many more genes apart from erythropoietin, and the elucidation of the oxygen‐dependent mechanisms degrading the HIF a subunits.
Signalling hypoxia by HIF hydroxylases.
HIF-1 in cell cycle regulation, apoptosis, and tumor progression.
TLDR
The current knowledge of oxygen-dependent HIF-1 activation mechanisms based on its structure is summarized and the proposed mechanisms through which Hif-1 regulates cellular proliferation of different cell types, including tumor cells as well as non-transformed, nonimmortalized cells under normoxic and hypoxic conditions are described.
The oxygen sensor factor-inhibiting hypoxia-inducible factor-1 controls expression of distinct genes through the bifunctional transcriptional character of hypoxia-inducible factor-1alpha.
TLDR
It is proposed that the oxygen-sensitive attenuator FIH, together with two distinct TADs, is central in setting the gene expression repertoire dictated by the cell pO(2).
Cellular oxygen sensing: Crystal structure of hypoxia-inducible factor prolyl hydroxylase (PHD2).
TLDR
The structure of the catalytic domain of human PHD2 provides insights into the hypoxic response, helps to rationalize a clinically observed mutation leading to familial erythrocytosis, and will aid in the design of PHD selective inhibitors for the treatment of anemia and ischemic disease.
Regulation of mammalian O2 homeostasis by hypoxia-inducible factor 1.
  • G. Semenza
  • Biology
    Annual review of cell and developmental biology
  • 1999
TLDR
HIF-1 appears to function as a master regulator of O2 homeostasis that plays essential roles in cellular and systemic physiology, development, and pathophysiology.
Oxygen sensing by HIF hydroxylases
TLDR
The transcription factor HIF (hypoxia-inducible factor) has a central role in oxygen homeostasis in animals ranging from nematode worms to man and is regulated by an unprecedented signalling mechanism that involves post-translational hydroxylation.
Cell-specific regulation of hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha stabilization and transactivation in a graded oxygen environment.
TLDR
A conserved amino acid substitution between Hif-1alpha and HIF-2alpha is characterized that contributes to the intrinsically higher FIH-1-mediated asparaginyl hydroxylation of H IF-1 alpha and, hence, lower HIF -1alpha activity.
Proline hydroxylation and gene expression.
  • W. Kaelin
  • Biology
    Annual review of biochemistry
  • 2005
TLDR
These findings provide new mechanistic insights into oxygen sensing by metazoans and are the first examples of protein hydroxylation being used in intracellular signaling.
HIF prolyl‐hydroxylase 2 is the key oxygen sensor setting low steady‐state levels of HIF‐1α in normoxia
TLDR
It is shown that specific ‘silencing’ of PHD2 with short interfering RNAs is sufficient to stabilize and activate HIF‐1α in normoxia in all the human cells investigated, concluding that, in vivo, PHDs have distinct assigned functions.
...
1
2
3
4
5
...