Oxygen sensing, homeostasis, and disease.

@article{Semenza2011OxygenSH,
  title={Oxygen sensing, homeostasis, and disease.},
  author={Gregg L Semenza},
  journal={The New England journal of medicine},
  year={2011},
  volume={365 6},
  pages={
          537-47
        }
}
Hypoxia plays critical roles in the pathobiology of heart disease, cancer, stroke, and chronic lung disease, which are responsible for 60% of deaths in the United States. This review summarizes advances in our un derstanding of how cells sense and respond to changes in oxygen availability and the physiologic or pathologic consequences of these responses in the context of chronic diseases. The role of hypoxia in inflammatory disorders was recently reviewed in the Journal 1 and is therefore not… CONTINUE READING

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