Oxygen-regulated protein-150 prevents calcium homeostasis deregulation and apoptosis induced by oxidized LDL in vascular cells

@article{Sanson2008OxygenregulatedPP,
  title={Oxygen-regulated protein-150 prevents calcium homeostasis deregulation and apoptosis induced by oxidized LDL in vascular cells},
  author={Marie Sanson and C Ingueneau and C{\'e}cile Vindis and J. Cl. Thiers and Yves Glock and Herv{\'e} Rousseau and Yoshiki Sawa and Yoshio Bando and Ziad Mallat and Robert Salvayre and Anne N{\`e}gre-Salvayre},
  journal={Cell Death and Differentiation},
  year={2008},
  volume={15},
  pages={1255-1265}
}
Oxidized LDLs (oxLDLs) induce apoptosis, which contributes to the pathogenesis of atherosclerosis. The 150 kDa oxygen-regulated protein (ORP150), an endoplasmic reticulum (ER)-resident chaperone, is upregulated by hypoxia and prevents ischemia-induced cell death. The aim of this work was to investigate whether and how ORP150 can prevent apoptosis induced by oxLDLs in vascular cells. OxLDLs induced ORP150 expression in the ER of human microvascular endothelial cell line (HMEC-1). ORP150… CONTINUE READING

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ORP150/HSP12A protects renal tubular epithelium from ischemia-induced cell death.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology • 2004

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