Oxygen radicals in ulcerative colitis.

  title={Oxygen radicals in ulcerative colitis.},
  author={C F Babbs},
  journal={Free radical biology & medicine},
  volume={13 2},
  • C F Babbs
  • Published 1992 in Free radical biology & medicine
This article reviews the pathophysiologic concept that superoxide and hydrogen peroxide, generated by activated leukocytes, together with low-molecular-weight chelate iron derived from fecal sources and from denatured hemoglobin, amplify the inflammatory response and subsequent mucosal damage in patients with active episodes of ulcerative colitis. The putative pathogenic mechanisms reviewed are as follows: (1) Dietary iron is concentrated in fecal material owing to normally limited iron… CONTINUE READING