Oxygen radicals and the nervous system

@article{Halliwell1985OxygenRA,
  title={Oxygen radicals and the nervous system},
  author={Barry Halliwell and John M. C. Gutteridge},
  journal={Trends in Neurosciences},
  year={1985},
  volume={8},
  pages={22-26}
}
An endogenous source of the superoxide anion in the central nervous system.
While it is known that oxygen intermediates, i.e., the superoxide radical anion, hydrogen peroxide, and the hydroxyl radical are toxic1–3, their role in pathological processes in the central nervous
Formation of Excess Reactive Oxygen Species within the Brain
The terms free radicals or oxygen radicals have become commonly used in the past decade as a result of overwhelming data suggesting that oxygen radicals are involved in a variety of disease
Free radical mechanisms in the central nervous system: an overview.
  • J. Cadet
  • Psychology
    The International journal of neuroscience
  • 1988
TLDR
An overview of the nature of free radicals is provided and briefly their participation in the toxicity associated with catecholamines in the CNS is discussed.
Oxygen radicals: common mediators of neurotoxicity.
Oxygen radicals and human disease.
TLDR
Attention is focused on cigarette smoke oxidants, ischemia-reperfusion-induced radical production, carcinogenesis, and aging, which may well provide a firm foundation for therapeutic breakthroughs in oxy-radical research.
Free radicals in central nervous system ischemia.
Free radicals have been implicated in a wide variety of diseases and in the toxic and therapeutic effects of antineoplastic drugs and radiation, the deleterious consequences of environmental
Reactive Oxygen Species and the Central Nervous System
TLDR
The nature of antioxidants is discussed, it being suggested that antioxidant enzymes and chelators of transition metal ions may be more generally useful protective agents than chain‐breaking antioxidants.
Oxygen radicals as key mediators in neurological disease: Fact or fiction?
TLDR
Criteria for establishing free radicals involvement in the pathology of several neurological disorders are presented and development of new methods for measuring oxidative damage should enable elucidation of the precise role of reactive oxygen species in neurological disorders.
Increased Cerebral Free Radical Production During Thiamine Deficiency
TLDR
Findings suggest that increased formation of free radicals occurs during the more acute symptomatic stage of thiamine deficiency and may contribute to the structural damage described in this model of Wernicke's encephalopathy.
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