Oxygen radical-mediated injury of myocytes-protection by propranolol.

  title={Oxygen radical-mediated injury of myocytes-protection by propranolol.},
  author={Iu Tong Mak and Jay Harlan Kramer and Anthony M. Freedman and Susanna Y. H. Tse and William Bernard Weglicki},
  journal={Journal of molecular and cellular cardiology},
  volume={22 6},
UIe effects of propranolol and atenolol on free radical mediated injury in myocytes were examined. Freshly isolated adult canine myocytes were incubated with a superoxide generating (from dihydroxyfumarate) and Fe-catalyzed free radical system. Exposure of the myocytes to free radicals for 20 min resulted in more than a 5-fold increase in thiobarbituric acid reactant (peroxide) formation and elevated levels of lactate dehydrogenase (LDH) activity released into the media compared to controls… CONTINUE READING

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