Oxygen radical injury and loss of high-energy compounds in anoxic and reperfused rat heart: prevention by exogenous fructose-1,6-bisphosphate.

@article{Tavazzi1990OxygenRI,
  title={Oxygen radical injury and loss of high-energy compounds in anoxic and reperfused rat heart: prevention by exogenous fructose-1,6-bisphosphate.},
  author={Barbara Tavazzi and L Cerroni and Donato Di Pierro and Giuseppe Lazzarino and Matti Nuutinen and Joseph W. Starnes and Bruno Giardina},
  journal={Free radical research communications},
  year={1990},
  volume={10 3},
  pages={167-76}
}
Isolated Langendorff-perfused rat hearts after 10 minutes preperfusion, were subjected to a substrate-free anoxic perfusion (20 minutes) followed by 20 minutes reperfusion with a glucose-containing oxygen-balanced medium. Under the same perfusion conditions, the effect of exogenous 5mM fructose-1,6-bisphosphate has been investigated. The xanthine dehydrogenase to xanthine oxidase ratio, concentrations of high-energy phosphates and of TBA-reactive material (TBARS) were determined at the end of… CONTINUE READING