Oxygen radical-dependent expression of CXC chemokines regulate ischemia/reperfusion-induced leukocyte adhesion in the mouse colon.

@article{Riaz2003OxygenRE,
  title={Oxygen radical-dependent expression of CXC chemokines regulate ischemia/reperfusion-induced leukocyte adhesion in the mouse colon.},
  author={Amjid Ali Riaz and Ren{\'e} Schramm and Tadashi Sato and Michael Dieter Menger and Bengt W. Jeppsson and Henrik Thorlacius},
  journal={Free radical biology & medicine},
  year={2003},
  volume={35 7},
  pages={782-9}
}
Activation and accumulation of leukocytes constitute a rate-limiting step in ischemia/reperfusion (I/R)-induced tissue injury. The signalling mechanisms, however, that regulate leukocyte rolling and adhesion in the colonic microcirculation are not known. The objective of the study was to define the role of CXC chemokines (MIP-2 and KC) in I/R-induced leukocyte-endothelial cell interactions in the mouse colon. In C57/B16 mice, colonic ischemia was induced by clamping the superior mesenteric… CONTINUE READING