Oxygen microbubbles improve tumor control after radiotherapy in a rat fibrosarcoma model


It is well-established that tumor hypoxia negatively impacts treatment outcome for radiation therapy (RT). In particular, tumor cell resistance to radiotherapy is increased 3-fold under anoxic conditions. Hypoxia hinders direct “oxygen radiosensitization” (increased free radical oxidative damage and formation of difficult-to-repair organic peroxides during… (More)


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