Oxygen metabolism by endothelial nitric-oxide synthase.

  title={Oxygen metabolism by endothelial nitric-oxide synthase.},
  author={Ying Tong Gao and Linda J. Roman and P Martasek and Satya Prakash Panda and Yuzuru Ishimura and Bettie Sue Siler Masters},
  journal={The Journal of biological chemistry},
  volume={282 39},
Nitric-oxide synthase (NOS) catalyzes both coupled and uncoupled reactions that generate nitric oxide and reactive oxygen species. Oxygen is often the overlooked substrate, and the oxygen metabolism catalyzed by NOS has been poorly defined. In this paper we focus on the oxygen stoichiometry and effects of substrate/cofactor binding on the endothelial NOS isoform (eNOS). In the presence of both L-arginine and tetrahydrobiopterin, eNOS is highly coupled (>90%), and the measured stoichiometry of O… CONTINUE READING
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