Oxygen-mediated regulation of gelatinase and tissue inhibitor of metalloproteinases-1 expression by invasive cells.

@article{Canning2001OxygenmediatedRO,
  title={Oxygen-mediated regulation of gelatinase and tissue inhibitor of metalloproteinases-1 expression by invasive cells.},
  author={Matthew T Canning and Lynne-Marie Postovit and Stephen H. Clarke and Charles H. Graham},
  journal={Experimental cell research},
  year={2001},
  volume={267 1},
  pages={88-94}
}
The relative expression of matrix metalloproteinases (MMPs) and tissue inhibitors of MMPs (TIMPs) is an important determinant in trophoblast invasion of the uterus and tumor invasion and metastasis. Our previous studies have shown that low oxygen levels increase the in vitro invasiveness of trophoblast and tumor cells. The present study examined whether changes in oxygen levels affect TIMP and MMP expression by cultured trophoblast and breast cancer cells. Reverse zymographic analysis… CONTINUE READING

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