Oxygen-mediated heterogeneity of apo-low-density lipoprotein.

  title={Oxygen-mediated heterogeneity of apo-low-density lipoprotein.},
  author={J. Schuh and Gordon F. Fairclough and R H Haschemeyer},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={75 7},
Mild oxidation of human serum low-density lipoprotein (LDL) converts the apoprotein from a nearly homogeneous component of high apparent molecular weight to a mixture of apparently lower molecular weight polypeptide components, as characterized by sodium dodecyl sulfate/polyacrylamide gel electrophoresis. This protein alteration, which correlates temporally with increases in the formation of lipid oxidation products and in the fluorescence of the apoprotein, is markedly reduced when oxygen is… CONTINUE READING


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