Oxygen-mediated cell injury in the killing of cultured hepatocytes by acetaminophen.

  title={Oxygen-mediated cell injury in the killing of cultured hepatocytes by acetaminophen.},
  author={Ronald J Gerson and A Casini and D Gilfor and Ada Serroni and John L. Farber},
  journal={Biochemical and biophysical research communications},
  volume={126 3},
Sensitivity of cultured hepatocytes to acetaminophen was induced by pretreatment of the rat with 3-methylcholanthrene. Under these conditions, 10 uM B-naphthoflavone but not SKF-525A prevented the cell killing, indicating dependence on metabolism. Inhibition of glutathione reductase by 50 uM bis-chloro-nitrosourea, shown previously to increase the sensitivity of hepatocytes to an oxidative stress, potentiated the toxicity of acetaminophen without increasing the covalent binding of acetaminophen… CONTINUE READING
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