Oxygen is not required for degradation of DNA by glutathione and Cu(II).

@article{Jain1996OxygenIN,
  title={Oxygen is not required for degradation of DNA by glutathione and Cu(II).},
  author={Abhinav Jain and N K Alvi and John Howard Parish and Sheikh Mumtaz Hadi},
  journal={Mutation research},
  year={1996},
  volume={357 1-2},
  pages={83-8}
}
Previous studies by others have shown that thiols, such as glutathione, cause cleavage of DNA in the presence of Cu(II) ions and that the hydroxyl radical derived from molecular oxygen is the major cleaving species. In this paper, we present several lines of evidence that strongly suggest that molecular oxygen is not essential for DNA cleavage and that thiyl radicals may also be involved. Indirect evidence is presented to indicate that glutathione may substitute oxygen as an electron acceptor… CONTINUE READING