Oxygen-insensitive nitroreductases: analysis of the roles of nfsA and nfsB in development of resistance to 5-nitrofuran derivatives in Escherichia coli.

@article{Whiteway1998OxygeninsensitiveNA,
  title={Oxygen-insensitive nitroreductases: analysis of the roles of nfsA and nfsB in development of resistance to 5-nitrofuran derivatives in Escherichia coli.},
  author={J. N. Whiteway and Peter Koziarz and J Veall and Noreen Sandhu and Parveen Kumar and B Hoecher and Iain B Lambert},
  journal={Journal of bacteriology},
  year={1998},
  volume={180 21},
  pages={5529-39}
}
Nitroheterocyclic and nitroaromatic compounds constitute an enormous range of chemicals whose potent biological activity has significant human health and environmental implications. The biological activity of nitro-substituted compounds is derived from reductive metabolism of the nitro moiety, a process catalyzed by a variety of nitroreductase activities. Resistance of bacteria to nitro-substituted compounds is believed to result primarily from mutations in genes encoding oxygen-insensitive… CONTINUE READING