Oxygen inhibits neuronal activation in the trigeminocervical complex after stimulation of trigeminal autonomic reflex, but not during direct dural activation of trigeminal afferents.

@article{Akerman2009OxygenIN,
  title={Oxygen inhibits neuronal activation in the trigeminocervical complex after stimulation of trigeminal autonomic reflex, but not during direct dural activation of trigeminal afferents.},
  author={Simon Akerman and Philip Robert Holland and Michele P Lasalandra and Peter J Goadsby},
  journal={Headache},
  year={2009},
  volume={49 8},
  pages={1131-43}
}
OBJECTIVE To understand the mechanism of action of oxygen treatment in cluster headache. BACKGROUND Trigeminal autonomic cephalalgias, including cluster headache, are characterized by unilateral head pain in association with ipsilateral cranial autonomic features. They are believed to involve activation of the trigeminovascular system and the parasympathetic outflow to the cranial vasculature from the superior salivatory nucleus (SuS) projections through the sphenopalatine ganglion, via the… CONTINUE READING
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Randomized double-blind, placebo-controlled trial of high-flow inhaled oxygen in acute cluster headache

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