Oxygen induces S-phase growth arrest and increases p53 and p21(WAF1/CIP1) expression in human bronchial smooth-muscle cells.

@article{Shenberger1999OxygenIS,
  title={Oxygen induces S-phase growth arrest and increases p53 and p21(WAF1/CIP1) expression in human bronchial smooth-muscle cells.},
  author={Jeffrey S. Shenberger and Patricia S. Dixon},
  journal={American journal of respiratory cell and molecular biology},
  year={1999},
  volume={21 3},
  pages={
          395-402
        }
}
Hyperoxia increases free radical production, leading to DNA damage. Recent studies indicate that oxygen augments the expression of p53 and p21(WAF1/CIP1), and increases apoptotic labeling of airway epithelial cells. Similar changes in regulatory gene products have not been reported in other pulmonary cells, nor have these changes been investigated in conjunction with alterations in cell-cycle distribution. The present study was conducted to determine whether oxygen alters the expression of p53… CONTINUE READING
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