Oxygen-induced retinopathy in the newborn rat: effects of hyperbarism and topical administration of timolol maleate

@article{Ricci1995OxygeninducedRI,
  title={Oxygen-induced retinopathy in the newborn rat: effects of hyperbarism and topical administration of timolol maleate},
  author={Benedetto Ricci and G. Minicucci and Alessandra Manfredi and Alessandro Santo},
  journal={Graefe's Archive for Clinical and Experimental Ophthalmology},
  year={1995},
  volume={233},
  pages={226-230}
}
• Background: Lesions resembling those of human retinopathy of prematurity can be provoked in newborn Wistar rats by exposure to an FiO2 of 80% for the first 5 days of life followed by 5 days recovery under room-air conditions. • Methods: We evaluated the effects of moderate hyperbarism (+60.75 kPa, i.e. 455 mmHg or 0.6 atm) and topical administration of 0.25% timolol maleate on oxygen-induced retinopathy (OIR) in this experimental model. • Results: OIR (including neovascularization in most… CONTINUE READING