Oxygen-induced maturation of SOD1: a key role for disulfide formation by the copper chaperone CCS.

@article{Furukawa2004OxygeninducedMO,
  title={Oxygen-induced maturation of SOD1: a key role for disulfide formation by the copper chaperone CCS.},
  author={Yoshiaki Furukawa and Andrew S. Torres and Thomas V. O'Halloran},
  journal={The EMBO journal},
  year={2004},
  volume={23 14},
  pages={2872-81}
}
The antioxidant enzyme Cu,Zn-superoxide dismutase (SOD1) has the distinction of being one of the most abundant disulfide-containing protein known in the eukaryotic cytosol; however, neither catalytic nor physiological roles for the conserved disulfide are known. Here we show that the disulfide status of Saccharomyces cerevisiae SOD1 significantly affects… CONTINUE READING