Oxygen-induced hypercarbia in obstructive pulmonary disease.

  title={Oxygen-induced hypercarbia in obstructive pulmonary disease.},
  author={William F Dunn and Sid Nelson and Rolf D. Hubmayr},
  journal={The American review of respiratory disease},
  volume={144 3 Pt 1},
We investigated the mechanisms responsible for oxygen-induced hypercarbia in ventilator-dependent patients with advanced chronic obstructive pulmonary disease (COPD). To quantitate the effects of oxygen (O2) on respiratory drive, we determined the CO2 recruitment threshold (PCO2 RT) in 10 mechanically ventilated patients under normoxic (PaO2 = 67 +/- 7 mm… CONTINUE READING