Oxygen-induced constriction of rabbit ductus arteriosus occurs via inhibition of a 4-aminopyridine-, voltage-sensitive potassium channel.

@article{TristaniFirouzi1996OxygeninducedCO,
  title={Oxygen-induced constriction of rabbit ductus arteriosus occurs via inhibition of a 4-aminopyridine-, voltage-sensitive potassium channel.},
  author={M Tristani-Firouzi and Helen L. Reeve and Simona Tolarova and Edward Kenneth Weir and Stephen L Archer},
  journal={The Journal of clinical investigation},
  year={1996},
  volume={98 9},
  pages={1959-65}
}
The ductus arteriosus is a vital fetal structure allowing blood ejected from the right ventricle to bypass the pulmonary circulation in utero. Closure of the ductus arteriosus at birth, essential for postnatal adaptation, is initiated by an increase in oxygen (O2) tension. We recently demonstrated the presence of O2-sensitive potassium channels in the fetal and adult pulmonary circulation which regulate vascular tone in response to changes in O2 tension. In this study, we assessed the cellular… CONTINUE READING
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