Oxygen free radicals and platelet activation.

  title={Oxygen free radicals and platelet activation.},
  author={Luigi Iuliano and Antonio Colavita and Regine Leo and Domenico Pratic{\`o} and Francesco Violi},
  journal={Free radical biology & medicine},
  volume={22 6},
This article reviews our current understanding of the role of oxygen free radicals in platelet activation. Several studies have indicated that platelets, in analogy to other circulating blood cells, are able to produce oxygen free radicals, which are likely to play an important role in the mechanism of platelet activation and aggregation. Platelet activation has been obtained with very low, physiologically relevant concentrations of radicals generated chemically, by leukocytes, and by… CONTINUE READING


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