Oxygen free radicals and myocardial damage: protective role of thiol-containing agents.

@article{Ferrari1991OxygenFR,
  title={Oxygen free radicals and myocardial damage: protective role of thiol-containing agents.},
  author={Roberto Ferrari and Claudio Ceconi and Salvatore Curello and Anna Cargnoni and Ottavio R. Alfieri and Alessandro Pardini and Paolo Marzollo and Odoardo Visioli},
  journal={The American journal of medicine},
  year={1991},
  volume={91 3C},
  pages={
          95S-105S
        }
}
It has been suggested that the sudden presence of oxygen during reperfusion after a period of ischemia may be toxic for the myocardial cell. The oxygen molecule is capable of producing reactions in the cell, forming highly reactive free radicals, and inducing lipid peroxidation of membranes, altering their integrity and increasing their fluidity and permeability. The ischemic and reperfused cardiac cell is the prime candidate for this reaction sequence and may explain the molecular mechanism… CONTINUE READING
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