Oxygen free radical signaling in ischemic preconditioning.

  title={Oxygen free radical signaling in ischemic preconditioning.},
  author={Dipak Kumar Das and Richard Engelman and Nilanjana Maulik},
  journal={Annals of the New York Academy of Sciences},
This review will focus on the free radical signaling mechanism of preconditioning. The results from our laboratory as well as studies from other laboratories suggest that reactive oxygen species function as second messenger during myocardial adaptation to ischemia. This review provides evidence for the first time that tyrosine kinase and MAP kinases are the targets for reactive oxygen species generated in the preconditioned myocardium. The finding that p38 MAP kinase might be upstream of NF… CONTINUE READING