Oxygen free radical-induced damage during colonic ischemia/reperfusion in rats

@article{Bhaskar1995OxygenFR,
  title={Oxygen free radical-induced damage during colonic ischemia/reperfusion in rats},
  author={Lakshmi Bhaskar and Minnie M. Mathan and K. V. Balasubramanian},
  journal={Molecular and Cellular Biochemistry},
  year={1995},
  volume={151},
  pages={9-14}
}
Reperfusion injury following ischemia is thought to be the consequence of reactive oxygen species. Role of these free radicals on the damaging effects of ischemia in colon has been investigated. A rat experimental model was used in which colon was subjected to ischemia and reperfusion and mucosal damage was assessed by biochemical and histological studies. Activity of myeloperoxidase, a neutrophil marker, was increased after ischemia (I) and ischemia/Reperfusion (I/R). Lipid peroxidation… CONTINUE READING