Oxygen-derived species: their relation to human disease and environmental stress.

  title={Oxygen-derived species: their relation to human disease and environmental stress.},
  author={Barry Halliwell and Carroll E. Cross},
  journal={Environmental Health Perspectives},
  pages={5 - 12}
Free radicals and other reactive oxygen species (ROS) are constantly formed in the human body, often for useful metabolic purposes. Antioxidant defenses protect against them, but these defenses are not completely adequate, and systems that repair damage by ROS are also necessary. Mild oxidative stress often induces antioxidant defense enzymes, but severe stress can cause oxidative damage to lipids, proteins, and DNA within cells, leading to such events as DNA strand breakage and disruption of… CONTINUE READING
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