Oxygen-derived free radicals related injury in the heart during ischemia and reperfusion.

@article{Kobayashi1989OxygenderivedFR,
  title={Oxygen-derived free radicals related injury in the heart during ischemia and reperfusion.},
  author={A Kobayashi and Hiroshi Watanabe and Kimiyoshi Ozawa and Hideharu Hayashi and Noriko Yamazaki},
  journal={Japanese circulation journal},
  year={1989},
  volume={53 9},
  pages={1122-31}
}
It has been suggested recently that oxygen-derived free radicals may play an important role in the genesis of reperfusion injury and arrhythmias. Free radicals have a very short half-life (ranging from mili- to microseconds), hence almost all the reports supporting the free radical hypothesis of reperfusion cell injury have been indirect. We have applied electrone spin resonance spectrometry to measure directly the amount of free radicals generated during ischemia and reperfusion. The… CONTINUE READING