Oxygen-derived free radicals in postischemic tissue injury.

  title={Oxygen-derived free radicals in postischemic tissue injury.},
  author={J M Mccord},
  journal={The New England journal of medicine},
  volume={312 3},
  • J M Mccord
  • Published 1985 in The New England journal of medicine
It is now clear that oxygen-derived free radicals play an important part in several models of experimentally induced reperfusion injury. Although there are certainly multiple components to clinical ischemic and reperfusion injury, it appears likely that free-radical production may make a major contribution at certain stages in the progression of the injury. The primary source of superoxide in reperfused reoxygenated tissues appears to be the enzyme xanthine oxidase, released during ischemia by… CONTINUE READING
Highly Influential
This paper has highly influenced a number of papers. REVIEW HIGHLY INFLUENTIAL CITATIONS