Oxygen-dependent regulation of the activating transcription factor-4 (ATF-4)

@inproceedings{Wottawa2010OxygendependentRO,
  title={Oxygen-dependent regulation of the activating transcription factor-4 (ATF-4)},
  author={Marieke Wottawa},
  year={2010}
}
The prolyl-4 hydroxylase domain enzymes 1-3 (PHD1-3) are involved in regulating the protein stability of the alpha subunit of the hypoxia inducible factor (HIF), which is the master regulator of oxygen-dependent gene expression. Increasing evidence has been found that the PHDs are involved in regulating additional, HIF-independent, oxygen-dependent signal transduction pathways. Additionally, several hints for isoform-specific functions of the PHDs were observed. Therefore, members of the… CONTINUE READING

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