Oxygen-dependent regulation of mitochondrial respiration by hypoxia-inducible factor 1.

  title={Oxygen-dependent regulation of mitochondrial respiration by hypoxia-inducible factor 1.},
  author={Gregg L. Semenza},
  journal={The Biochemical journal},
  volume={405 1},
  • G. Semenza
  • Published 1 July 2007
  • Biology
  • The Biochemical journal
The survival of metazoan organisms is dependent upon the utilization of O2 as a substrate for COX (cytochrome c oxidase), which constitutes Complex IV of the mitochondrial respiratory chain. Premature transfer of electrons, either at Complex I or at Complex III, results in the increased generation of ROS (reactive oxygen species). Recent studies have identified two critical adaptations that may function to prevent excessive ROS production in hypoxic cells. First, expression of PDK1 [PDH… 

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