Oxygen dependency and precision of cytochrome oxidase signal from full spectral NIRS of the piglet brain.

@article{Springett2000OxygenDA,
  title={Oxygen dependency and precision of cytochrome oxidase signal from full spectral NIRS of the piglet brain.},
  author={Roger Springett and John Newman and Mark Cope and David T. Delpy},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2000},
  volume={279 5},
  pages={H2202-9}
}
Oxidation changes of the copper A (Cu(A)) center of cytochrome oxidase in the brain were measured during brief anoxic swings at both normocapnia and hypercapnia (arterial PCO(2) approximately 55 mmHg). Hypercapnia increased total hemoglobin from 37.5 +/- 9.1 to 50.8 +/- 12.9 micromol/l (means +/- SD; n = 7), increased mean cerebral saturation (Smc(O(2))) from 65 +/- 4 to 77 +/- 3%, and oxidized Cu(A) by 0.43 +/- 0.23 micromol/l. During the onset of anoxia, there were no significant changes in… CONTINUE READING

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Regulation of oxygen supply in the cerebral circulation.

Advances in experimental medicine and biology • 1997
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